Androgen deprivation of prostate cancer: Leading to a therapeutic dead end

•Androgen deprivation therapy (ADT) leads to numerous molecular alterations in prostate cancer.•ADT promotes more aggressive behavior and metastasis of tumor cells.•ADT ends in incurable castration resistant disease.•ADT of advanced prostate cancer leads to a reduced efficacy of anticancer agents.•T...

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Bibliographic Details
Published in:	Cancer letters 2015-10, Vol.367 (1), p.12-17
Main Authors:	Katzenwadel, Arndt, Wolf, Philipp
Format:	Article
Language:	English
Subjects:	Androgen Antagonists - adverse effects Androgen Antagonists - therapeutic use Androgen deprivation therapy Androgens Animals Antineoplastic Agents, Hormonal - adverse effects Antineoplastic Agents, Hormonal - therapeutic use Cancer therapies Castration resistance Chemotherapy Diabetes Disease Progression Drug Design Drug Resistance, Neoplasm Drugs Gene expression Hematology, Oncology and Palliative Medicine Humans Ligands Male Metastasis Molecular alterations Molecular Targeted Therapy Mortality Neoplasm Recurrence, Local Patients Prostate cancer Prostatic Neoplasms, Castration-Resistant - drug therapy Prostatic Neoplasms, Castration-Resistant - metabolism Prostatic Neoplasms, Castration-Resistant - mortality Prostatic Neoplasms, Castration-Resistant - pathology Proteins Regulatory approval Signal Transduction - drug effects Studies Testosterone Treatment Outcome Tumors
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