Zein/gum Arabic nanoparticle-stabilized Pickering emulsion with thymol as an antibacterial delivery system

•Zein and GA were fabricated into nanoparticles to stabilize Pickering emulsions.•Thymol was loaded into the ZGP-stabilized Pickering emulsions.•ZGP-thymol Pickering emulsion had a stronger antibacterial activity (E. coli).•ZGP-thymol Pickering emulsion exhibited a controlled-release effect. Zein/gu...

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Bibliographic Details
Published in:Carbohydrate polymers 2018-11, Vol.200, p.416-426
Main Authors: Li, Juan, Xu, Xueer, Chen, Zhengxing, Wang, Tao, Lu, Zhengjie, Hu, Weicheng, Wang, Li
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Antibacterial activity
Drug Carriers - chemistry
Drug Liberation
Drug Stability
Emulsions
Food Safety
Gum Arabic
Gum Arabic - chemistry
Nanoparticles - chemistry
Oils - chemistry
Pickering
Rheology
Sodium Chloride - chemistry
Stability
Thymol
Thymol - chemistry
Water - chemistry
Zein
Zein - chemistry
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Summary:•Zein and GA were fabricated into nanoparticles to stabilize Pickering emulsions.•Thymol was loaded into the ZGP-stabilized Pickering emulsions.•ZGP-thymol Pickering emulsion had a stronger antibacterial activity (E. coli).•ZGP-thymol Pickering emulsion exhibited a controlled-release effect. Zein/gum Arabic (GA) nanoparticles (ZGPs) were fabricated to stabilize the oil-water interface of a Pickering emulsion. The Pickering emulsion was successfully fabricated at an oil fraction of 0.3 with 6.25% concentration of ZGPs. The droplet size and creaming index of the Pickering emulsions were influenced significantly by the concentrations of the ZGPs and oil fractions. Morphological observations showed that droplet aggregation occurred when the concentrations of ZGPs decreased or the oil fraction increased. The interfacial tension and rheological properties of the Pickering emulsions indicated that the ZGPs formed a stable oil-water interfacial layer and limited agglomeration and Ostwald ripening. Thymol loaded ZGP-stabilized Pickering emulsion was able to significantly inhibit the growth of E. coli. In addition, the ZGP-stabilized Pickering emulsion with thymol exhibited a controlled-release effect of thymol and antibacterial activity due to the protective effect of the stable interfacial layer of the ZPGs.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2018.08.025