Dietary Inflammatory Score Is Associated With Incident Heart Failure In The Reasons For Geographic And Racial Differences In Stroke Study

• Published in: Journal of cardiac failure 2023-04, Vol.29 (4), p.639-639
• Main Authors: Park, Christine, Balkan, Lauren, Bryan, Joanna, Shikany, James, Judd, Suzanne, Bostick, Roberd, Jonas, Chanel, Sterling, Madeline, Brown, Todd, Hummel, Scott, Arora, Pankaj, Durant, Raegan, Jackson, Elizabeth, Levitan, Emily, Safford, Monika, Goyal, Parag
• Format: Article
• Language: English
• ISSN: 1071-9164; 1532-8414
• DOI: 10.1016/j.cardfail.2022.10.227

Inflammation is a well-established risk factor for heart failure (HF) via processes that lead to atherosclerosis, myocardial fibrosis, and dysfunction. Dietary patterns can influence systemic inflammation, but an association between a “pro-inflammatory diet” and incident HF has not been reported. Higher dietary inflammatory score (DIS) is associated with incident HF events. A total of 17,975 participants without suspected HF at baseline in the national Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort of individuals age 45 years and older and recruited 2003-7 were examined. The exposure for this analysis was a validated novel dietary inflammatory score (DIS) derived from the baseline food frequency questionnaire. The outcome was incident expert adjudicated HF hospitalization or HF death. Cox proportional hazard models were used to determine the association between DIS and incident HF, adjusting for baseline total energy intake, demographics, social determinants of health, pro-inflammatory lifestyle behaviors (tobacco use, physical inactivity, alcohol use), physiologic factors, and comorbid conditions. The mean age of the sample was 64±9.2 years, 55.8% were women, and 32.3% were Black. Over a median follow-up of 11.1 years, there were a total of 900 HF events (752 HF hospitalizations and 148 HF deaths). Compared to DIS Q1, Q4 was associated with higher risk of incident HF events (HR 1.29, 95% CI 1.03-1.61) in a fully adjusted model (Figure). This study in a large, diverse US cohort highlights the relationship between diet, inflammation, and incident HF. Dietary patterns may be a modifiable lifestyle factor for prevention of HF.