Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia: A comparative approach

Hydrogen sulfide (H2S), nitric oxide (NO) and nitrite (NO2−) are formed in vivo and are of crucial importance in the tissue response to hypoxia, particularly in the cardiovascular system, where these signaling molecules are involved in a multitude of processes including the regulation of vascular to...

Full description

Saved in:
Bibliographic Details
Published in:Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Molecular & integrative physiology, 2012-05, Vol.162 (1), p.1-6
Main Authors: Fago, Angela, Jensen, Frank B., Tota, Bruno, Feelisch, Martin, Olson, Kenneth R., Helbo, Signe, Lefevre, Sjannie, Mancardi, Daniele, Palumbo, Anna, Sandvik, Guro K., Skovgaard, Nini
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Animals
cardiovascular system
Cytoprotection
Gasotransmitter
Humans
hydrogen sulfide
Hydrogen Sulfide - metabolism
hypoxia
Hypoxia - metabolism
Hypoxia - physiopathology
nitric oxide
Nitric Oxide - metabolism
Nitric Oxide Synthase - physiology
nitrites
Nitrites - metabolism
Oxygen sensing
S-nitrosothiols
Signal Transduction
Vasoconstriction
Vasodilation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hydrogen sulfide (H2S), nitric oxide (NO) and nitrite (NO2−) are formed in vivo and are of crucial importance in the tissue response to hypoxia, particularly in the cardiovascular system, where these signaling molecules are involved in a multitude of processes including the regulation of vascular tone, cellular metabolic function and cytoprotection. This report summarizes current advances on the mechanisms by which these signaling pathways act and may have evolved in animals with different tolerance to hypoxia, as presented and discussed during the scientific sessions of the annual meeting of the Society for Experimental Biology in 2011 in Glasgow. It also highlights the need and potential for a comparative approach of study and collaborative effort to identify potential link(s) between the signaling pathways involving NO, nitrite and H2S in the whole-body responses to hypoxia.
ISSN:1095-6433
1531-4332
DOI:10.1016/j.cbpa.2012.01.011