Elevated soluble programmed death-ligand 1 levels indicate immunosuppression and poor prognosis in hepatocellular carcinoma patients undergoing transcatheter arterial chemoembolization

•sPD-L1 level was significantly elevated in patients with poor HCC outcomes after TACE.•High sPD-L1 was an independent predictive indicator for HCC prognosis after TACE.•High sPD-L1 correlated with high sIL-2R, IL-10 and HBV-loads, which indicated immunosuppressive status.•High sPD-L1 levels correla...

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Published in:Clinica chimica acta 2020-12, Vol.511, p.67-74
Main Authors: Ma, Xiao-Lu, Qu, Xu-Dong, Yang, Wen-Jing, Wang, Bei-Li, Shen, Min-Na, Zhou, Yan, Zhang, Chun-Yan, Sun, Yun-Fan, Chen, Jian-Wen, Hu, Bo, Gong, Zi-Jun, Zhang, Xin, Pan, Bai-Shen, Zhou, Jian, Fan, Jia, Yang, Xin-Rong, Guo, Wei
Format: Article
Language:English
Subjects:
B7-H1 Antigen
Biomarkers, Tumor
Carcinoma, Hepatocellular - therapy
Chemoembolization, Therapeutic
Hepatocellular carcinoma
Humans
Immunosuppression
Immunosuppression Therapy
Liver Neoplasms - therapy
Prognosis
Soluble programmed death-ligand 1
Transcatheter arterial chemoembolization
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Summary:•sPD-L1 level was significantly elevated in patients with poor HCC outcomes after TACE.•High sPD-L1 was an independent predictive indicator for HCC prognosis after TACE.•High sPD-L1 correlated with high sIL-2R, IL-10 and HBV-loads, which indicated immunosuppressive status.•High sPD-L1 levels correlated with increased numbers of Treg cells, Macrophage cells, and M2-Macrophage cells. The present study aimed to determine the prognostic significance of soluble Programmed Death-ligand 1 (sPD-L1) in hepatocellular carcinoma (HCC) patients undergoing transcatheter arterial chemoembolization (TACE). We treated 114 HCC patients with TACE from 2012 to 2013 and determined their sPD-L1 levels by enzyme-linked immunosorbent assay. We evaluated prognosis according to mRESIST criteria and analyzed prognostic values by Cox regression and Kaplan-Meier analysis. We further evaluated correlations between sPD-L1 level and inflammatory status, as well as immunosuppressive environment. sPD-L1 levels were significantly increased in patients who developed HCC progression (P = 0.002) and death (P 
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2020.09.026