Translation dysregulation in cancer as a source for targetable antigens

Aberrant peptides presented by major histocompatibility complex (MHC) molecules are targets for tumor eradication, as these peptides can be recognized as foreign by T cells. Protein synthesis in malignant cells is dysregulated, which may result in the generation and presentation of aberrant peptides...

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Published in:	Cancer cell 2025-05, Vol.43 (5), p.823-840.e18
Main Authors:	Weller, Chen, Bartok, Osnat, McGinnis, Christopher S., Palashati, Heyilimu, Chang, Tian-Gen, Malko, Dmitry, Shmueli, Merav D., Nagao, Asuteka, Hayoun, Deborah, Murayama, Ayaka, Sakaguchi, Yuriko, Poulis, Panagiotis, Khatib, Aseel, Erlanger Avigdor, Bracha, Gordon, Sagi, Cohen Shvefel, Sapir, Zemanek, Marie J., Nielsen, Morten M., Boura-Halfon, Sigalit, Sagie, Shira, Gumpert, Nofar, Yang, Weiwen, Alexeev, Dmitry, Kyriakidou, Pelgia, Yao, Winnie, Zerbib, Mirie, Greenberg, Polina, Benedek, Gil, Litchfield, Kevin, Petrovich-Kopitman, Ekaterina, Nagler, Adi, Oren, Roni, Ben-Dor, Shifra, Levin, Yishai, Pilpel, Yitzhak, Rodnina, Marina, Cox, Jürgen, Merbl, Yifat, Satpathy, Ansuman T., Carmi, Yaron, Erhard, Florian, Suzuki, Tsutomu, Buskirk, Allen R., Olweus, Johanna, Ruppin, Eytan, Schlosser, Andreas, Samuels, Yardena
Format:	Article
Language:	English
Subjects:	Animals Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology cancer immunopeptidome Cell Line, Tumor Humans immune checkpoint blockade Immune Checkpoint Inhibitors - pharmacology Immunotherapy - methods Mice neoantigens Neoplasms - genetics Neoplasms - immunology non-canonical peptides Programmed Cell Death 1 Receptor - antagonists & inhibitors Protein Biosynthesis translation fidelity
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