A novel synthesis route to furo[3,2-a]carbazole

In this paper, we report a novel approach to the heteroaryl-condensed nuclei of natural furo[3,2- a]carbazole alkaloids. Our synthetic studies use N-phthaloyl tryptophan methyl ester as starting material and zinc ion mediated transamination reaction as the key step. This work also implicated a novel...

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Bibliographic Details
Published in:Chinese chemical letters 2015-03, Vol.26 (3), p.282-284
Main Authors: Xu, Mei, Fan, Tian-Yun, Zhang, Jian-Xin, Hao, Xiao-Jiang, Liu, Sheng
Format: Article
Language:English
Subjects:
Furo[3,2-a]carbazole
Synthesis
Transamination
合成路线
呋喃
咔唑
生物碱
起始原料
转移反应
邻苯二甲酰
锌离子
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Summary:In this paper, we report a novel approach to the heteroaryl-condensed nuclei of natural furo[3,2- a]carbazole alkaloids. Our synthetic studies use N-phthaloyl tryptophan methyl ester as starting material and zinc ion mediated transamination reaction as the key step. This work also implicated a novel strategy to assemble other [a]-fused carbazoles.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2014.11.026