An ionic liquid-reinforced gelatin hydrogel with strong adhesion, antibacterial and anti-inflammatory properties for treating oral ulcers

Oral ulcers may greatly diminish patient life quality and potentially result in malignant transformations. Using gels or films as pseudomembrane barriers is an effective method for promoting ulcer healing. However, these pseudomembranes face challenges such as saliva flushing, dynamic changes, and t...

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Bibliographic Details
Published in:Chinese chemical letters 2024-09, p.110441, Article 110441
Main Authors: Chen, Mengyu, Zhou, Qinglin, Qin, Tianyun, Sun, Ningyao, Chen, Yuxi, Gong, Yuwei, Li, Xingyi, Liu, Jinsong
Format: Article
Language:English
Subjects:
Adhesive hydrogel
Injectability
Ionic liquids
Methacrylated gelatin
Oral ulcers
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Summary:Oral ulcers may greatly diminish patient life quality and potentially result in malignant transformations. Using gels or films as pseudomembrane barriers is an effective method for promoting ulcer healing. However, these pseudomembranes face challenges such as saliva flushing, dynamic changes, and the presence of abundant microorganisms in the complex oral environment. Herein, we developed an injectable, photoinduction, in situ-enhanceable oral ulcer repair hydrogel (named as GIL2) by incorporating dynamic phenylboronic acid ester bonds and imidazole ions into a methacrylated gelatin matrix. GIL2 exhibited rapid gelation (3 seconds), low swelling properties (1.07 g/g), robust tensile strength (56.83 kPa) and high adhesive strength (63.38 kPa), allowing it to adhere effectively to the ulcer surface. Moreover, the GIL2 demonstrated intrinsic antibacterial and antioxidant qualities. Within a diabetic rat model for oral ulcers, GIL2 effectively eased oxidative stress and decreased the inflammation present in ulcerated wounds, thereby greatly hastening the healing process of these ulcers. Together, GIL2 hydrogel demonstrates remarkable adaptability within the oral milieu, revitalizing clinical strategy advancements for treating bacterial-infected oral ulcers. [Display omitted] An ionic liquid-reinforced gelatin hydrogel was engineered for treating oral ulcers, characterized by swift gelation (3 seconds), minimal swelling properties (1.07 g/g), strong tensile strength (56.83 kPa), and superior adhesive strength (63.38 kPa).
ISSN:1001-8417
DOI:10.1016/j.cclet.2024.110441