Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation

Members of the mammalian phosphoinositide-3-OH kinase (PI3K) family of proteins are critical regulators of various cellular process including cell survival, growth, proliferation, and motility. Oncogenic activating mutations in the p110α catalytic subunit of the heterodimeric p110/p85 PI3K enzyme ar...

Full description

Saved in:

Bibliographic Details
Published in:	Cancer cell 2009-12, Vol.16 (6), p.463-474
Main Authors:	Jaiswal, Bijay S., Janakiraman, Vasantharajan, Kljavin, Noelyn M., Chaudhuri, Subhra, Stern, Howard M., Wang, Weiru, Kan, Zhengyan, Dbouk, Hashem A., Peters, Brock A., Waring, Paul, Dela Vega, Trisha, Kenski, Denise M., Bowman, Krista K., Lorenzo, Maria, Li, Hong, Wu, Jiansheng, Modrusan, Zora, Stinson, Jeremy, Eby, Michael, Yue, Peng, Kaminker, Josh S., de Sauvage, Frederic J., Backer, Jonathan M., Seshagiri, Somasekar
Format:	Article
Language:	English
Subjects:	CELLCYCLE SIGNALING
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!