Beyond sole models for the first steps of Pt-DNA interactions: Fundamental properties of mono(nucleobase) adducts of PtII coordination compounds

• Published in: Coordination chemistry reviews 2022-08, Vol.465, p.214566, Article 214566
• Main Authors: Lippert, Bernhard, Sanz Miguel, Pablo J.
• Format: Article
• Language: English
• Subjects: Chirality; Cyclic derivatives; Head–tail dimers; Pt-nucleobase chemistry
• ISSN: 0010-8545; 1873-3840
• DOI: 10.1016/j.ccr.2022.214566

[Display omitted] •Mono(nucleobase) compounds of PtII as models for primary nucleic acid adducts.•Mono(nucleobase) compounds of PtII as precursors for mixed-nucleobase complexes.•Mono(nucleobase) compounds of PtII as precursors for multinuclear and cyclic condensation products.•Chirality of mono(nucleobase) compounds of PtII and their head–tail dinuclear derivatives. A major feature of mono(nucleobase) complexes of PtII containing one or more aqua ligands is their ability to engage in intermolecular condensation reactions leading to multinuclear species with bridging nucleobases, bridging hydroxido or amido ligands. Their chemistry appears to be more versatile with isolated model nucleobases than is the case when relevant PtII species interact with nucleic acids. Special emphasis of this review article is on compounds obtained with pyrimidine model nucleobases (1-methylcytosine, 1-metylthymine, 1-methyluracil) and their cyclic condensation products. Aspects of chirality of mononuclear as well as head–tail dinuclear species will be discussed.