Green synthesis of N-substituted benzimidazoles: The promising methicillin resistant Staphylococcus aureus (MRSA) inhibitors

The current investigation describes the synthesis of N-substituted phenyl acetamide benzimidazole based derivatives 3(a-f) and their systematic analysis against Methicillin Resistant Staphylococcus aureus (MRSA). These compounds were characterized by IR, 1H NMR, 13C NMR spectrometry, elemental analy...

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Bibliographic Details
Published in:Chemical Data Collections 2020-02, Vol.25, p.100344, Article 100344
Main Authors: Chaudhari, Sanjay R., Patil, Pramod N., Patil, Ulhas K., Patel, Harun M., Rajput, Jamatsing D., Pawar, Nilesh S., Patil, Dipak B.
Format: Article
Language:English
Subjects:
MRSA
Substituted benzimidazoles
Synthesis
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Summary:The current investigation describes the synthesis of N-substituted phenyl acetamide benzimidazole based derivatives 3(a-f) and their systematic analysis against Methicillin Resistant Staphylococcus aureus (MRSA). These compounds were characterized by IR, 1H NMR, 13C NMR spectrometry, elemental analysis and Mass. The derivative 2-(1H-benzimidazol-1-yl)-N-(3-nitrophenyl) acetamide (3f) exhibited significant potent antibacterial activity (6 fold more potent as compared to the standard drug Sultamicillin) against the MRSA (ATCC 4330). The structural correlationship indicates that m-nitro phenyl at N-position of benzimidazole strongly favours the anti-MRSA activity compared to the p-nitro phenyl. [Display omitted]
ISSN:2405-8300
2405-8300
DOI:10.1016/j.cdc.2020.100344