NIR light triggered size variable “remote-controlled cluster bomb” for deep penetration and tumor therapy

•A novel antitumor nanoplatform was designed and synthesized.•The prepared nanomedicine showed deep penetration and high accumulation.•Light-responsive nanomedicine exhibited controlled drug release. Poor penetration into tumor stem cells of nanomedicine leads to the low therapeutic efficacy, metast...

Full description

Saved in:
Bibliographic Details
Published in:Chemical engineering journal (Lausanne, Switzerland : 1996) Switzerland : 1996), 2019-11, Vol.375, p.122080, Article 122080
Main Authors: Cao, Weiwei, He, Yuchu, Zhu, Ruiyan, He, Yaqian, Hao, Zining, Zhao, Qianqian, He, Hongyu, Wang, Shuai, Li, Chunhui, Gao, Dawei
Format: Article
Language:English
Subjects:
Deep penetration
Gold nanorods
Polydopamine
Remoted-controlled cluster bomb
Structure-tunable nanosystem
Tumor therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•A novel antitumor nanoplatform was designed and synthesized.•The prepared nanomedicine showed deep penetration and high accumulation.•Light-responsive nanomedicine exhibited controlled drug release. Poor penetration into tumor stem cells of nanomedicine leads to the low therapeutic efficacy, metastasis and recurrence of tumors. Herein, doxorubicin (DOX) modified gold nanorods (GNRs) and chlorin e6 (Ce6) were loaded simultaneously on the surface of polydopamine (PDA) nanospheres (PDA@GNRs-DOX/Ce6), which was called structure-tunable “remote-controlled cluster bomb”. The “cluster bomb” were accumulated primarily to the tumor tissues via enhanced permeability and retention effect. Subsequently, the nanosystem was disintegrated to release DOX and singlet oxygen and kill the superficial tumor cells under NIR laser irradiation. Meanwhile, the small-size GNRs (48 nm × 15 nm) fall off from the primary nanocarriers and penetrated into the interior tumor tissue to damage the tumor stem cells. The novel variable structure nanosystem avoided the possibility of tumor metastasis and recurrence. The results also verified its excellent tumor therapeutic efficiency, the relative tumor volume was 0.47 ± 0.31 in the PDA@GNRs-DOX/Ce6 group, which was lower significantly than that of control group (26.50 ± 0.98). We believe the design of structure-tunable “remote-controlled cluster bomb” can provide an inspiration for the future tumor therapy.
ISSN:1385-8947
1873-3212
DOI:10.1016/j.cej.2019.122080