High-temperature liquid chromatography for evaluation of the efficiency of multiwalled carbon nanotubes as nano extraction beds for removal of acidic drugs from wastewater. Greenness profiling and comprehensive kinetics and thermodynamics studies

• Published in: Journal of Chromatography A 2021-02, Vol.1639, p.461891, Article 461891
• Main Authors: Al-Khateeb, Lateefa A., Al-zahrani, Mona A., El Hamd, Mohamed A., El-Maghrabey, Mahmoud, Dahas, Fatimah A., El-Shaheny, Rania
• Format: Article
• Language: English
• Subjects: Adsorption kinetics and thermodynamics; Extraction beds; Green protocol; HTLC; MWCNTs; Wastewater treatment
• ISSN: 0021-9673
• DOI: 10.1016/j.chroma.2021.461891

•Thermodynamic description of the retention of a series of acidic drugs on heat resistant column.•Study of MWCNTs as nano extraction beds for removal of acidic drugs from wastewater.•The adsorption kinetically follows pseudo-second-order, while thermodynamically, it is exothermic and enthalpy driven.•The MWCNTs showed excellent adsorption efficiency ranged from 76.4 to 97.6% and good binding capacities.•This protocol is greener than reported literature for the removal of acidic drugs from wastewater. The retention behavior of a series of acidic drugs, namely ketoprofen (KET), naproxen (NAP), diclofenac (DIC), and ibuprofen (IBU), on the heat-resisting ZORBAX 300SB-C18 column, was studied thermodynamically using high-temperature liquid chromatography (HTLC). A perfect correlation of the compounds' lipophilicity and the calculated thermodynamic indicators evidenced its contribution to the retention behavior. Besides, the steric fitting has a subsidiary effect on IBU retention. Isocratic HTLC separation of the four compounds was achieved using an aqueous mobile phase containing 30% acetonitrile-0.2% acetic acid-0.2% triethylamine at 60 °C. This method has been utilized to monitor the adsorption efficiency of multiwalled carbon nanotubes (MWCNTs) for the removal of the four NSAIDs from water. Different variables affecting the remediation process have been optimized such as the time of contact, pH, ionic strength, temperature, and the mass of MWCNTs. The kinetics and thermodynamics of the adsorption were investigated. The adsorption was evidenced to take place via pseudo-second-order kinetics and the intraparticle diffusion is the rate-controlling step. The thermodynamic investigation showed that the adsorption process is exothermic and enthalpy-driven, and the adsorption is more extensive at a lower temperature. The MWCNTs showed excellent adsorption efficiency of about 76.4 to 97.6% at the optimum conditions. The obtained results are promising and encouraging for the full-scale application of MWCNTs for remediation of NSAIDs-related water pollution. The green analytical chemistry metric “AGREE” and the analytical eco-scale score tool confirmed that the developed protocol is greener and more favorable to the environment and user than most of the reported literature.