Reliability of motor cortex transcranial magnetic stimulation in four muscle representations

• Published in: Clinical neurophysiology 2006-05, Vol.117 (5), p.1037-1046
• Main Authors: Malcolm, M.P., Triggs, W.J., Light, K.E., Shechtman, O., Khandekar, G., Gonzalez Rothi, L.J.
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Brain Mapping; Differential Threshold - radiation effects; Dose-Response Relationship, Radiation; Electrodiagnosis. Electric activity recording; Electromyography - methods; Evoked Potentials, Motor - radiation effects; Female; Functional Laterality; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Motor cortex; Motor Cortex - physiology; Motor Cortex - radiation effects; Muscle, Skeletal - physiology; Muscle, Skeletal - radiation effects; Nervous system; Neurology; Neuroplasticity; Reliability; Transcranial Magnetic Stimulation; Vascular diseases and vascular malformations of the nervous system
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2006.02.005

Motor cortex plasticity may underlie motor recovery after stroke. Numerous studies have used transcranial magnetic stimulation (TMS) to investigate motor system plasticity. However, research on the reliability of TMS measures of motor cortex organization and excitability is limited. We sought to test the reliability of these TMS measurements. Twenty healthy volunteers were tested twice over a two-week period using TMS to determine motor threshold, map topography, and stimulus–response curves for first dorsal interosseous (FDI), abductor pollicis brevis (APB), extensor digitorum communis (EDC), and flexor carpi radialis (FCR) muscles. We found moderate to good test–retest reliability TMS measurements of motor threshold (ICC=0.90–0.97), map area (ICC=0.63–0.86) and location (ICC=0.69–0.86), and stimulus–response curves (ICC=0.60–0.83). TMS assessments of motor representation size, location, and excitability are generally reliable measures, although their reliability may vary according to the muscle under investigation. These results suggest that TMS measurements of motor cortex function are reliable enough to be potentially useful in investigation of motor system plasticity.