Multiple sclerosis fatigue relief by bilateral somatosensory cortex neuromodulation

Multiple sclerosis-related fatigue is highly common and often refractory to medical therapy. Ten fatigued multiple sclerosis patients received two blocks of 5-day anodal bilateral primary somatosensory areas transcranial direct current stimulation in a randomized, doubleblind sham-controlled, cross-...

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Bibliographic Details
Published in:Clinical neurophysiology 2016-03, Vol.127 (3), p.e24-e25
Main Authors: Tecchio, F, Cancelli, A, Cottone, C, Zito, G, Pasqualetti, P, Ghazaryan, A, Rossini, P.M, Filippi, M.M
Format: Article
Language:English
Subjects:
Neurology
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Summary:Multiple sclerosis-related fatigue is highly common and often refractory to medical therapy. Ten fatigued multiple sclerosis patients received two blocks of 5-day anodal bilateral primary somatosensory areas transcranial direct current stimulation in a randomized, doubleblind sham-controlled, cross-over study. The real neuromodulation by a personalized electrode, shaped on the MRderived primary somatosensory cortical strip, reduced fatigue in all patients, by 26% in average ( p = 0.002), which did not change after sham ( p = 0.901). Anodal tDCS over bilateral somatosensory areas was able to relief fatigue in mildly disabled MS patients, when the fatigue related symptoms severely hamper their quality of life. These small-scale study results support the concept that interventions modifying the sensorimotor network activity balances could be a suitable non-pharmacological treatment for multiple sclerosis fatigue.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2015.11.070