O164 Different patterns of dysautonomia in relapsing and progressive multiple sclerosis

To determine differences in autonomic dysfunction in patients with relapsing remitting multiple sclerosis (RMMS) and progressive forms of MS (PMS). Forty RRMS (33 females,35.45±9.15, median EDSS 1.25, median disease duration 923days) and 30 PPMS (17 females, 48.03±10.58, median EDSS 6.5, median dise...

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Bibliographic Details
Published in:Clinical neurophysiology 2017-09, Vol.128 (9), p.e231-e231
Main Authors: Crnosija, Luka, Adamec, Ivan, Skoric, Magdalena Krbot, Gabelic, Tereza, Habek, Mario
Format: Article
Language:English
Subjects:
Autonomic nervous system
CASS
Multiple sclerosis
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Summary:To determine differences in autonomic dysfunction in patients with relapsing remitting multiple sclerosis (RMMS) and progressive forms of MS (PMS). Forty RRMS (33 females,35.45±9.15, median EDSS 1.25, median disease duration 923days) and 30 PPMS (17 females, 48.03±10.58, median EDSS 6.5, median disease duration 4538days) patients were enrolled. The following autonomic tests were performed: heart rate and blood pressure responses to the Valsalva maneuver, heart rate response to deep breathing (RSA), blood pressure response to passive tilt and Quantitative Sudomotor Axon Reflex Test (QSART). All tests were interpreted in the form of the composite autonomic scoring scale (CASS). Median CASS was 1 (range 0 to 5) and 3 (range 0 to 6) for RRMS and PMS patients, respectively. Patients with PMS had significantly higher adrenergic, cardiovagal, sudomotor indices and total CASS compared to patients with RRMS (p=0.029, p=0.018, p
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2017.07.174