FV 5. MRI-based texture analysis of the corpus callosum in progressive supranuclear palsy

• Published in: Clinical neurophysiology 2021-08, Vol.132 (8), p.e31-e31
• Main Authors: Barlescu, L.A., Müller, H.P., Ludolph, A.C., Pinkhardt, E.H., Huppertz, H.J., Kassubek, J.
• Format: Article
• Language: English
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2021.02.381

Introduction. The diagnosis of progressive supranuclear palsy (PSP) involves head MRI, including detection of atrophy patterns of the mesencephalon and frontoparietal regions. In this study, MRI-based alterations of the texture in the corpus callosum (CC) in PSP patients compared with Parkinson's disease(PD) patients and healthy controls were investigated. Methods. In sagittal T1-weighted MRI scans of 66 PSP patients, 66 PD patients and 44 healthy controls the corpus callosum was segmented by atlas-based volumetry and TIFT [1] in areas I-V based on the Hofer & Frahm scheme [2]. The texture parameters entropy and homogeneity were calculated separately for areas I-V and results were compared for PSP patients (including phenotypes Richardson-syndrome and PSP-parkinsonism) vs. PD patients vs. healthy controls. Results. A significant increase of parameters entropy and homogeneity compared to controls was detected for PSP as well as for PD for areas I, II, and III of the CC; here PSP patients showed a higher increase compared to PD patients. Highest alterations were detected in area II where the increase of (in)homogeneity of PSP compared with PD was significant. Differences between the phenotypes Richardson-syndrome und PSP-parkinsonism could not be shown. Discussion. Texture analysis of the CC could contribute to diagnosis, screening and differentiation between PSP and PD. References [1] Müller HP, et al. Neuroimage Clin. 2020; 26:102223. [2] Hofer S, Frahm J. Neuroimage. 2006; 32,989-994.