Antioxidant and anti-inflammatory response to curcumin supplementation in hemodialysis patients: A randomized, double-blind, placebo-controlled clinical trial

• Published in: Clinical nutrition ESPEN 2021-08, Vol.44, p.136-142
• Main Authors: Rodrigues, Hellen Christina Neves, Martins, Tatiane Fagundes Pereira, Santana, Nayara Cristina Freitas e Silva, Braga, Clarice Carneiro, Silva, Marina Alves Coelho, Cunha, Luiz Carlos da, Sugizaki, Clara Sandra de Araújo, Freitas, Ana Tereza Vaz de Souza, Costa, Nara Aline, Peixoto, Maria do Rosário Gondim
• Format: Article
• Language: English
• Subjects: Chronic kidney disease; Curcumin; Inflammation; Oxidative stress; Renal dialysis
• ISSN: 2405-4577; 2405-4577
• DOI: 10.1016/j.clnesp.2021.06.006

Hemodialysis (HD) patients are vulnerable to malnutrition and cardiovascular complications due to many factors, including oxidative stress and inflammation. Curcumin supplementation is associated with attenuation of proinflammatory cytokines and increased activity of antioxidant enzymes, but its effects in HD patients are unknown. This study aimed to evaluate the effect of curcumin supplementation on oxidative stress and inflammation in HD patients. This randomized, double-blind, placebo-controlled trial enrolled 43 HD patients and divided them into two groups: supplemented with curcumin (1 g/day) or placebo (corn starch) for 12 weeks. Demographic information and blood samples were taken at the start and the end of the study to determine serum malondialdehyde (MDA) concentrations, antioxidant enzyme activity, and high-sensitivity C-reactive protein (hs-CRP). The curcumin group showed a significant increase in catalase activity [Δ = 1.13 ± 2.87 versus Δ = −1.08 ± 2.68; p = 0.048] and preserved glutathione peroxidase activity [Δ = −4.23 ± 11.50 versus Δ = −14.44 ± 13.96; p