Hypofractionated Radiotherapy for T1N0M0 Glottic Cancer: Retrospective Analysis of Two Different Cohorts of Dose-fractionation Schedules from a Single Institution

Abstract Aims To determine the influence of dose and fractionation on tumour characteristics, toxicity, disease control and survival outcomes in T1 glottic carcinoma. Materials and methods Between 1975 and 2000, treatment charts of 652 patients with T1 glottic carcinoma who received curative radiati...

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Published in:Clinical oncology (Royal College of Radiologists (Great Britain)) 2012-12, Vol.24 (10), p.e180-e186
Main Authors: Laskar, S.G, Baijal, G, Murthy, V, Chilukuri, S, Budrukkar, A, Gupta, T, Agarwal, J.P
Format: Article
Language:English
Subjects:
Aged
Cohort Studies
Dose Fractionation
Early vocal cord
Female
glottic cancer
Glottis - pathology
Glottis - radiation effects
Hematology, Oncology and Palliative Medicine
Humans
hypofractionated radiotherapy
Laryngeal Neoplasms - radiotherapy
Male
Middle Aged
Multivariate Analysis
Radiology
Radiotherapy Dosage
Retrospective Studies
Tongue Neoplasms - pathology
Tongue Neoplasms - radiotherapy
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Summary:Abstract Aims To determine the influence of dose and fractionation on tumour characteristics, toxicity, disease control and survival outcomes in T1 glottic carcinoma. Materials and methods Between 1975 and 2000, treatment charts of 652 patients with T1 glottic carcinoma who received curative radiation with four hypofractionated schedules (50 Gy/15 fractions [3.3 Gy/fraction] or 55 Gy/16 fractions [3.43 Gy/fraction] or 60 Gy/24 fractions or 62.5 Gy/25 fractions [2.5 Gy/fraction]) were analysed. The patients were divided into two groups based on fraction size 3 Gy. Local control and overall survival were calculated. Patient- and tumour-related factors affecting local control were analysed using univariate and multivariate analysis. Factors affecting late toxicity were also analysed. Results The local control and overall survival at 10 years were 84 and 86.1%, respectively, for T1 glottic carcinoma. The response to radiation had a significant effect on local control with univariate analysis ( P  = 0.001). Other factors, such as beam energy, anterior commissure involvement and fractionation, did not affect local control. Persistent radiation oedema was seen in 123 patients (23.4%) and was significantly worse in patients who received radiation with a larger field size (>36 cm2 ) on a telecobalt machine ( P  
ISSN:0936-6555
1433-2981
DOI:10.1016/j.clon.2012.07.001