SGLT2 Inhibition with Empagliflozin Increases Circulating Provascular Progenitor Cells in People with Type 2 Diabetes Mellitus

Hess et al. quantified circulating aldehyde dehydrogenase-expressing (ALDH ) cell subsets in people with T2DM given either empagliflozin (EMPA) or placebo. EMPA treatment increased circulating pro-angiogenic CD133 progenitor cells, decreased pro-inflammatory ALDH granulocyte precursors, and increase...

Full description

Saved in:
Bibliographic Details
Published in:Cell metabolism 2019-10, Vol.30 (4), p.609-613
Main Authors: Hess, David A, Terenzi, Daniella C, Trac, Justin Z, Quan, Adrian, Mason, Tamique, Al-Omran, Mohammed, Bhatt, Deepak L, Dhingra, Natasha, Rotstein, Ori D, Leiter, Lawrence A, Zinman, Bernard, Sabongui, Sandra, Yan, Andrew T, Teoh, Hwee, Mazer, C David, Connelly, Kim A, Verma, Subodh
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Benzhydryl Compounds - pharmacology
Benzhydryl Compounds - therapeutic use
Cardiotonic Agents - pharmacology
Cardiotonic Agents - therapeutic use
Cardiovascular Diseases - complications
Cardiovascular Diseases - drug therapy
Coronary Artery Disease - drug therapy
Diabetes Mellitus, Type 2 - complications
Glucosides - pharmacology
Glucosides - therapeutic use
Humans
Middle Aged
Myeloid Progenitor Cells - drug effects
Myeloid Progenitor Cells - physiology
Regeneration
Sodium-Glucose Transporter 2 Inhibitors - pharmacology
Sodium-Glucose Transporter 2 Inhibitors - therapeutic use
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hess et al. quantified circulating aldehyde dehydrogenase-expressing (ALDH ) cell subsets in people with T2DM given either empagliflozin (EMPA) or placebo. EMPA treatment increased circulating pro-angiogenic CD133 progenitor cells, decreased pro-inflammatory ALDH granulocyte precursors, and increased ALDH monocytes with M2 polarization. EMPA treatment improved T2DM-associated "regenerative cell depletion" contributing to enhanced vascular health.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2019.08.015