Sustained release nanofibrous composite patch for transdermal antibiotic delivery

[Display omitted] In this paper, Dextran, Polycaprolactone (PCL) and Graphene oxide (GO) were used to fabricate a nanofibrous transdermal patch by electrospinning for wound dressing. An antibacterial agent, tetracycline (TC) was incorporated in the composite patch. The physiochemical properties of t...

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Bibliographic Details
Published in:Colloids and surfaces. A, Physicochemical and engineering aspects Physicochemical and engineering aspects, 2020-02, Vol.586, p.124267, Article 124267
Main Authors: Nematpour, Najmeh, Farhadian, Negin, Ebrahimi, Kosar Sadat, Arkan, Elham, Seyedi, Faranak, Khaledian, Salar, Shahlaei, Mohsen, Moradi, Sajad
Format: Article
Language:English
Subjects:
Dextran
Graphene oxide
Nanofiber
Polycaprolactone
Tetracycline
Transdermal patch
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Summary:[Display omitted] In this paper, Dextran, Polycaprolactone (PCL) and Graphene oxide (GO) were used to fabricate a nanofibrous transdermal patch by electrospinning for wound dressing. An antibacterial agent, tetracycline (TC) was incorporated in the composite patch. The physiochemical properties of the as-prepared nanofiber was evaluated using FTIR and SEM. Swelling index, mechanical characteristics and release profile were also examined. A uniform nanofibrous structure with 50 nm of diameter was obtained using 50 % w/w dextran loaded by TC@GO. The interior part of the patch included TC loaded GO embedded on the dextran nanofiber was protected from moisture penetration by a supplemental hydrophobic PCL layer. Besides, the later layer improves the mechanical properties of the composite. Also drug release study of nano fibrous drug carrier showed a controlled-sustained release pattern of TC for up to three days. Finally the nano dressing has shown a good antibacterial activity against both E. coli and S. aureus hence it could be used as dermal patch for treatment of chronic infectious lesions.
ISSN:0927-7757
1873-4359
DOI:10.1016/j.colsurfa.2019.124267