Magnetic navigation helps PLGA drug loaded magnetic microspheres achieve precise chemoembolization and hyperthermia

• Published in: Colloids and surfaces. A, Physicochemical and engineering aspects Physicochemical and engineering aspects, 2020-03, Vol.588, p.124364, Article 124364
• Main Authors: Liang, Yi-Jun, Wang, Haoyao, Yu, Hui, Feng, Guodong, Liu, Fang, Ma, Ming, Zhang, Yu, Gu, Ning
• Format: Article
• Language: English
• Subjects: Drug release; Embolic microsphere; Magnetic hyperthermia; Magnetic navigation; Transcatheter arterial chemoembolization
• ISSN: 0927-7757; 1873-4359
• DOI: 10.1016/j.colsurfa.2019.124364

Utilizing PLGA drug loaded magnetic microspheres (PLGA-DMMs) for precise tumor chemoembolization and hyperthermia is expected to achieve under magnetic navigation. [Display omitted] •High performance PLGA-DMMs with well-controlled sizes were prepared by novel rotating membrane emulsification system.•The magnetically induced heating and vitro cytotoxicity, as well as the drug release behavior of PLGA-DMMs were studied systematically.•The magnetic gradient field analysis system was used to study the dynamic behavior of microspheres during embolization process. The poly-(lactic-co-glycolic acid) drug loaded magnetic microspheres (PLGA-DMMs) containing anti-tumor drug PTX with well-controlled sizes have been prepared by novel rotating membrane emulsification technique. Scanning electron microscopy and EDS showed that the as-prepared microspheres had regular shape while the C, O and Fe elements were observed distribution on the surface uniformly. The in vitro cytotoxicity and magnetically induced heating evaluation certified their well biocompatibility and excellent heating performance, respectively. The HPLC confirmed these as-prepared microspheres with fine drug loading coefficient 8.1 % along with 94.6 % encapsulation efficiency. In particular, PTX release behavior revealed that temperature had played a decisive role to affect the drug release during 90 days. We subsequently introduced the gradient magnetic field analysis system to simulate magnetic navigation embolization and help understanding the dynamic behavior of microspheres during this process. We believe that this work can not only enrich the fabrication of drug loaded magnetic microspheres with high performance, but also provide a valuable reference for achieving precise chemoembolization and hyperthermia via magnetic navigation in the future.