Direct synthesis of small-sized platinum nanoflowers loaded on carbon supports as highly efficient and stable uricase-like nanozyme

• Published in: Colloids and surfaces. A, Physicochemical and engineering aspects Physicochemical and engineering aspects, 2024-11, Vol.701, p.134763, Article 134763
• Main Authors: Liu, Yan, Jin, Lingcen, Zhang, Hongyan, Guo, Rong
• Format: Article
• Language: English
• Subjects: Nanocomposite; Nanozyme; Small-sized platinum nanoflowers; Urate crystal inhibitor; Uricase
• ISSN: 0927-7757
• DOI: 10.1016/j.colsurfa.2024.134763

The development of multifunctional and high-performance nanozymes via a facile strategy is especially intriguing for biomedical applications. Here, a surfactant-free simple method was used to successfully load small-sized Pt nanoflowers (PtNFs) onto reduced graphene oxide (rGO) based on single glucose. PtNF@rGO nanozyme (NM) exhibits highly excellent catalytic activity, and displays good stability and recyclability in degrading uric acid. More importantly, this robust integrated nanozyme shows strong sulfur resistance. The analysis of the structure-function relationship indicates that the small sized nanoflower structure and the interaction between PtNF and rGO in the integrated catalysts contribute to the catalytic activity and stability collectively. Interestingly, PtNF@rGO nanozymes can mimic the cascade processes of uricase/catalase to degrade both uric acid and H2O2. Furthermore, the inhibition effect of PtNF@rGO on the crystallization of urate crystals was investigated. PtNF@rGO nanozyme prolongs the nucleation induction time (from 10 to 72 h) during the crystallization of sodium urate significantly. This study reveals the significance of morphology regulation in constructing high-performance and multifunctional hybrid nanozymes, broadening the application of nanozyme in the biomedical field. [Display omitted] •Small-size Pt nanoflower (PtNF)@rGO hybrid is facilely prepared based on single glucose.•Synergistic effects of PtNF and rGO enhance uricase-like activity of the hybrid highly.•PtNF@rGO hybrid nanozyme shows strong sulfur resistance.•Self-cascade uricase/peroxidase mimics is obtained based on PtNF@rGO hybrid.•PtNF@rGO hybrid inhibits the crystallization of sodium urate significantly.