An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

Cellular senescence suppresses cancer by halting the growth of premalignant cells, yet the accumulation of senescent cells is thought to drive age-related pathology through a senescence-associated secretory phenotype (SASP), the function of which is unclear. To understand the physiological role(s) o...

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Bibliographic Details
Published in:Developmental cell 2014-12, Vol.31 (6), p.722-733
Main Authors: Demaria, Marco, Ohtani, Naoko, Youssef, Sameh A., Rodier, Francis, Toussaint, Wendy, Mitchell, James R., Laberge, Remi-Martin, Vijg, Jan, Van Steeg, Harry, Dollé, Martijn E.T., Hoeijmakers, Jan H.J., de Bruin, Alain, Hara, Eiji, Campisi, Judith
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Cell Differentiation
Cellular Senescence
Endothelial Cells - cytology
Female
Fibroblasts - metabolism
Luminescence
Male
Mesoderm - cytology
Mice
Mice, Transgenic
Myofibroblasts - metabolism
Platelet-Derived Growth Factor - chemistry
Platelet-Derived Growth Factor - metabolism
Transgenes
Wound Healing
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