The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base

Highly conserved intraflagellar transport (IFT) protein complexes direct both the assembly of primary cilia and the trafficking of signaling molecules. IFT complexes initially accumulate at the base of the cilium and periodically enter the cilium, suggesting an as-yet-unidentified mechanism that tri...

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Bibliographic Details
Published in:Developmental cell 2017-07, Vol.42 (1), p.22-36.e12
Main Authors: Kanie, Tomoharu, Abbott, Keene Louis, Mooney, Nancie Ann, Plowey, Edward Douglas, Demeter, Janos, Jackson, Peter Kent
Format: Article
Language:English
Subjects:
Animals
Cell Cycle Proteins - metabolism
Centrioles - metabolism
CEP19
CEP350
cilia
Cilia - metabolism
Ciliopathies
ciliopathy
FGFR1OP
Flagella - metabolism
Gene Knockout Techniques
Guanosine Triphosphate - metabolism
intraflagellar transport
Mice, Inbred C57BL
Mice, Knockout
Multiprotein Complexes - metabolism
Nucleotides - metabolism
obesity
Phenotype
Protein Binding
Protein Stability
Protein Transport
rab GTP-Binding Proteins - deficiency
rab GTP-Binding Proteins - metabolism
RABL2
Reproducibility of Results
retinal degeneration
small GTPase
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