YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis

Vascular endothelial growth factor (VEGF) is a major driver of blood vessel formation. However, the signal transduction pathways culminating in the biological consequences of VEGF signaling are only partially understood. Here, we show that the Hippo pathway effectors YAP and TAZ work as crucial sign...

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Bibliographic Details
Published in:	Developmental cell 2017-09, Vol.42 (5), p.462-478.e7
Main Authors:	Wang, Xiaohong, Freire Valls, Aida, Schermann, Géza, Shen, Ying, Moya, Ivan M., Castro, Laura, Urban, Severino, Solecki, Gergely M., Winkler, Frank, Riedemann, Lars, Jain, Rakesh K., Mazzone, Massimilano, Schmidt, Thomas, Fischer, Tamás, Halder, Georg, Ruiz de Almodóvar, Carmen
Format:	Article
Language:	English
Subjects:	Actin Cytoskeleton - genetics Adaptor Proteins, Signal Transducing - metabolism angiogenesis Animals Animals, Newborn Brain - pathology Cell Cycle Proteins Cell Line, Tumor Cell Membrane - metabolism Cell Movement - genetics Cell Nucleus - metabolism Chromatin Immunoprecipitation CNS vascularization Embryonic Development - genetics endothelial cells Endothelial Cells - metabolism Gene Deletion Gene Knockout Techniques Gene Silencing Golgi Apparatus - metabolism hippo pathway Mice Models, Biological Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Neovascularization, Physiologic - genetics Phosphoproteins - metabolism Signal Transduction - genetics TAZ Trans-Activators Transcription, Genetic Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-2 - metabolism VEGF VEGFR2 YAP YAP/TAZ
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