Oxidized albumin is associated with water retention and severity of disease in patients with chronic liver diseases

Summary Background & aims Serum albumin exists in oxidized and reduced forms. Although oxidation of albumin affects some functions of albumin, the involvement of oxidized albumin in disease progression and water retention in patients with chronic liver disease remains unclear. The aim of this st...

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Published in:e-SPEN, the European e-journal of clinical nutrition and metabolism the European e-journal of clinical nutrition and metabolism, 2010-12, Vol.5 (6), p.e247-e253
Main Authors: Sakata, Masahiro, Kawaguchi, Takumi, Taniguchi, Eitaro, Nakayama, Akira, Ishizaki, Sonoko, Sonaka, Ichiro, Nakamura, Toru, Itou, Minoru, Oriishi, Tetsuharu, Abe, Mitsuhiko, Yanagimoto, Chikatoshi, Koga, Hironori, Sata, Michio
Format: Article
Language:English
Subjects:
Albumin
Bioelectrical impedance analyzer
Edema
Gastroenterology and Hepatology
High-performance liquid chromatography
Internal Medicine
Liver disorder
Redox
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Summary:Summary Background & aims Serum albumin exists in oxidized and reduced forms. Although oxidation of albumin affects some functions of albumin, the involvement of oxidized albumin in disease progression and water retention in patients with chronic liver disease remains unclear. The aim of this study was to determine whether there is an association between oxidized albumin and water retention in patients with chronic liver disease. Methods Seventy-nine patients with chronic viral liver diseases and 31 cirrhotic patients with hypoalbuminemia were enrolled. The oxidized albumin percentage was determined by high-performance liquid chromatography. Water retention was assessed by the extra cellular fluid/total body fluid ratio (ECF/TBF) using a bioelectrical impedance analyzer. Results The oxidized albumin percentage was significantly increased according to disease progression (chronic hepatitis; 28.3 ± 1.1, Child A; 33.5 ± 1.2, Child B and C; 37.8 ± 1.3, P < 0.05). Moreover, the ECF/TBF showed a significant positive correlation with the oxidized albumin percentage ( P = 0.010, R2 = 0.161), but no correlation with serum albumin levels. A low proportion of oxidized albumin was an independent predictor of reduction in body weight (OR 10.6, 95%CI 1.304–86.307, P = 0.0272). Conclusions Oxidized albumin was related to disease progression and water retention in patients with chronic liver disease.
ISSN:1751-4991
1751-4991
DOI:10.1016/j.eclnm.2010.09.003