Concurrent irradiation with the anti-programmed cell death ligand-1 immune checkpoint blocker durvalumab: Single centre subset analysis from a phase 1/2 trial

To assess preliminary safety and efficacy results of the anti-programmed cell death ligand-1 (anti-PD-L1) durvalumab in combination with radiotherapy (RT) in an expansion cohort of patients included in a phase 1/2 trial at our institution. Data from patients who received concurrent palliative RT wit...

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Bibliographic Details
Published in:	European journal of cancer (1990) 2016-11, Vol.68, p.156-162
Main Authors:	Levy, Antonin, Massard, Christophe, Soria, Jean-Charles, Deutsch, Eric
Format:	Article
Language:	English
Subjects:	Adenocarcinoma - secondary Adenocarcinoma - therapy Adult Aged Aged, 80 and over Anti-PD-L1 Antibodies, Monoclonal - therapeutic use Antineoplastic Agents - therapeutic use B7-H1 Antigen - antagonists & inhibitors Bone Neoplasms - secondary Bone Neoplasms - therapy Brain Neoplasms - secondary Brain Neoplasms - therapy Breast Neoplasms - pathology Breast Neoplasms - therapy Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Carcinoma, Transitional Cell - secondary Carcinoma, Transitional Cell - therapy Chemoradiotherapy Colonic Neoplasms - pathology Colonic Neoplasms - therapy Disease-Free Survival Eye Neoplasms - pathology Eye Neoplasms - therapy Female Head and Neck Neoplasms - pathology Head and Neck Neoplasms - therapy Hematology, Oncology and Palliative Medicine Humans Immunoradiotherapy Kaplan-Meier Estimate Liver Neoplasms - secondary Liver Neoplasms - therapy Lung Neoplasms - pathology Lung Neoplasms - therapy Lymphatic Metastasis - radiotherapy Male Melanoma - secondary Melanoma - therapy Middle Aged Neoplasms - therapy Phase 1 Phase 2 Radiosurgery Radiotherapy Radiotherapy, Conformal Small Cell Lung Carcinoma - secondary Small Cell Lung Carcinoma - therapy Squamous Cell Carcinoma of Head and Neck Survival Rate Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - therapy
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