A systematic literature review and network meta-analysis of effectiveness and safety outcomes in advanced melanoma

Although a myriad of novel treatments entered the treatment paradigm for advanced melanoma, there is lack of head-to-head evidence. We conducted a network meta-analysis (NMA) to estimate each treatment's relative effectiveness and safety. A systematic literature review (SLR) was conducted in Em...

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Bibliographic Details
Published in:	European journal of cancer (1990) 2019-12, Vol.123, p.58-71
Main Authors:	Franken, Margreet G., Leeneman, Brenda, Gheorghe, Maria, Uyl-de Groot, Carin A., Haanen, John B.A.G., van Baal, Pieter H.M.
Format:	Article
Language:	English
Subjects:	Advanced melanoma Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - therapeutic use Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Anti–CTLA-4 Anti–PD-1 Azetidines - administration & dosage Azetidines - therapeutic use Bayesian analysis Benzimidazoles - administration & dosage Benzimidazoles - therapeutic use Binimetinib BRAF Cancer Vaccines - therapeutic use Carboplatin Carboplatin - administration & dosage Carboplatin - therapeutic use Clinical trials Cobimetinib Dabrafenib Dacarbazine Dacarbazine - administration & dosage Dacarbazine - therapeutic use Decision making Encorafenib gp100 Melanoma Antigen - immunology Homogeneity Humans Hydrazines - administration & dosage Hydrazines - therapeutic use Imidazoles - administration & dosage Imidazoles - therapeutic use Interleukin-2 - administration & dosage Interleukin-2 - therapeutic use Ipilimumab Ipilimumab - administration & dosage Ipilimumab - therapeutic use Lenalidomide - administration & dosage Lenalidomide - therapeutic use Literature reviews MEK Melanoma Melanoma - drug therapy Melanoma - immunology Melanoma - pathology Meta-analysis Monoclonal antibodies Network meta-analysis Nitrosourea Compounds - administration & dosage Nitrosourea Compounds - therapeutic use Nivolumab Nivolumab - administration & dosage Nivolumab - therapeutic use Optimization Organophosphorus Compounds - administration & dosage Organophosphorus Compounds - therapeutic use Oximes - administration & dosage Oximes - therapeutic use Paclitaxel Paclitaxel - administration & dosage Paclitaxel - therapeutic use Patients Pembrolizumab Piperidines - administration & dosage Piperidines - therapeutic use Population studies Progression-Free Survival Proportional Hazards Models Pyridones - administration & dosage Pyridones - therapeutic use Pyrimidinones - administration & dosage Pyrimidinones - therapeutic use Safety Skin Neoplasms - drug therapy Skin Neoplasms - immunology Skin Neoplasms - pathology Sorafenib - administration & dosage Sorafenib - therapeutic use Survival Survival Rate Systematic literature review Systematic review Targeted cancer therapy Temozolomide Temozolomide - administration & dosage Temozolomide - therapeutic use Trametinib Treatment Outcome Vemurafenib Vemurafenib - administration & dosage Vemurafenib - therapeutic use
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