Cardiac resynchronisation therapy: an option for inotrope-supported patients with end-stage heart failure?

Background: Patients with refractory heart failure requiring inotropic support have a very poor prognosis. Cardiac resynchronisation therapy (CRT) offers symptomatic and possibly a survival benefit for patients with stable chronic heart failure (CHF) and a prolonged QRS, but its role in the manageme...

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Bibliographic Details
Published in:European journal of heart failure 2005-03, Vol.7 (2), p.215-217
Main Authors: Cowburn, Peter J., Patel, Harshna, Jolliffe, Robynn E., Wald, Robert W., Parker, John D.
Format: Article
Language:English
Subjects:
Cardiac resynchronisation therapy
Congestive heart failure
Inotropes
Pacing
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Summary:Background: Patients with refractory heart failure requiring inotropic support have a very poor prognosis. Cardiac resynchronisation therapy (CRT) offers symptomatic and possibly a survival benefit for patients with stable chronic heart failure (CHF) and a prolonged QRS, but its role in the management of end‐stage heart failure requiring inotropic support has not been evaluated. Methods: We performed a retrospective observational study of patients undergoing CRT at our institution. Results: We identified 10 patients who required inotropic support for refractory CHF and who underwent CRT while on intravenous inotropic agents. Patients had been in hospital for 30±29 days and had received inotropic support for 11±6 days prior to CRT. All patients were weaned from inotropic support (2±2 days post‐CRT) and all patients survived to hospital discharge (12±13 days post‐CRT). Furosemide dose fell from 160±38 mg on admission to 108±53 mg on discharge (p
ISSN:1388-9842
1879-0844
DOI:10.1016/j.ejheart.2004.11.005