Desing and synthesis of potent anti-Trypanosoma cruzi agents new thiazoles derivatives which induce apoptotic parasite death

Chagas disease, caused by the kinetoplastid protozoan parasite Trypanosoma cruzi, remains a relevant cause of illness and premature death and it is estimated that 6 million to 7 million people are infected worldwide. Although chemotherapy options are limited presenting serious problems, such as low...

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Bibliographic Details
Published in:	European journal of medicinal chemistry 2017-04, Vol.130, p.39-50
Main Authors:	da Silva, Elany Barbosa, Oliveira e Silva, Dayane Albuquerque, Oliveira, Arsênio Rodrigues, da Silva Mendes, Carlos Henrique, dos Santos, Thiago André Ramos, da Silva, Aline Caroline, de Castro, Maria Carolina Acioly, Ferreira, Rafaela Salgado, Moreira, Diogo Rodrigo Magalhães, Cardoso, Marcos Veríssimo de Oliveira, de Simone, Carlos Alberto, Pereira, Valéria Rêgo Alves, Leite, Ana Cristina Lima
Format:	Article
Language:	English
Subjects:	Apoptosis Apoptosis - drug effects Chagas disease Chagas Disease - drug therapy Cysteine Endopeptidases - drug effects Drug Design Nonclassical bioisosterism Parasitic Sensitivity Tests Protozoan Proteins - drug effects Pyridine derivatives Structure-Activity Relationship Thiazoles Thiazoles - chemistry Thiazoles - pharmacokinetics Trypanocidal Agents - chemistry Trypanocidal Agents - pharmacology Trypanosoma cruzi Trypanosoma cruzi - cytology Trypanosoma cruzi - drug effects
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