4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors

Resistance to β-lactam antibiotics in Gram-negatives producing metallo-β-lactamases (MBLs) represents a major medical threat and there is an extremely urgent need to develop clinically useful inhibitors. We previously reported the original binding mode of 5-substituted-4-amino/H-1,2,4-triazole-3-thi...

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Published in:	European journal of medicinal chemistry 2020-12, Vol.208, p.112720, Article 112720
Main Authors:	Gavara, Laurent, Sevaille, Laurent, De Luca, Filomena, Mercuri, Paola, Bebrone, Carine, Feller, Georges, Legru, Alice, Cerboni, Giulia, Tanfoni, Silvia, Baud, Damien, Cutolo, Giuliano, Bestgen, Benoît, Chelini, Giulia, Verdirosa, Federica, Sannio, Filomena, Pozzi, Cecilia, Benvenuti, Manuela, Kwapien, Karolina, Fischer, Marina, Becker, Katja, Frère, Jean-Marie, Mangani, Stefano, Gresh, Nohad, Berthomieu, Dorothée, Galleni, Moreno, Docquier, Jean-Denis, Hernandez, Jean-François
Format:	Article
Language:	English
Subjects:	1,2,4-Triazole-3-thione Bacterial resistance beta-LAcatamases beta-Lactamase Inhibitors Biochemistry, biophysics & molecular biology Biochimie, biophysique & biologie moléculaire Chemical Sciences Crystallography, X-Ray Escherichia col Escherichia coli Proteins Human Umbilical Vein Endothelial Cells Humans Life sciences Medicinal Chemistry Metallo-β-Lactamase Microbial Sensitivity Tests Microbiologie Microbiology Protein Binding Pseudomonas aeruginosa Schiff Bases Sciences du vivant Thiones Triazoles β-lactam antibiotic
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