Exposure to both formaldehyde and high relative humidity exacerbates allergic asthma by activating the TRPV4-p38 MAPK pathway in Balb/c mice

Some studies have indicated that formaldehyde, a ubiquitous environmental pollutant, can induce or aggravate allergic asthma. Epidemiological studies have also shown that the relative humidity indoors may be an independent and a key factor associated with the aggravation of allergic asthma. However,...

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Bibliographic Details
Published in:	Environmental pollution (1987) 2020-01, Vol.256, p.113375, Article 113375
Main Authors:	Duan, Jiufei, Xie, Jing, Deng, Ting, Xie, Xiaoman, Liu, Hong, Li, Baizhan, Chen, Mingqing
Format:	Article
Language:	English
Subjects:	Allergic asthma Animals asthma Asthma - chemically induced Asthma - immunology Asthma - metabolism calcium Disease Models, Animal epidemiological studies Formaldehyde Formaldehyde - toxicity High relative humidity histopathology Humidity - adverse effects hypersecretion Inflammation lung function lungs Male males Mice Mice, Inbred BALB C mitogen-activated protein kinase mucus ovalbumin Ovalbumin - immunology p38 MAPK p38 Mitogen-Activated Protein Kinases - metabolism pollutants relative humidity Respiratory Function Tests transient receptor potential vanilloid channels TRPV Cation Channels - metabolism TRPV4
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