Evolution of early perihemorrhagic changes—ischemia vs. edema

Cerebral ischemia has been proposed as a contributing mechanism to secondary neuronal injury after intracranial hemorrhage (ICH). The search for surrogate parameters that allow treatment stratification for spontaneous ICH continues. We aimed to examine perihemorrhagic ischemic changes with an animal...

Full description

Saved in:
Bibliographic Details
Published in:Experimental neurology 2005-06, Vol.193 (2), p.369-376
Main Authors: Orakcioglu, Berk, Fiebach, Jochen B., Steiner, Thorsten, Kollmar, Rainer, Jüttler, Eric, Becker, Kristina, Schwab, Stefan, Heiland, Sabine, Meyding-Lamadé, Uta K., Schellinger, Peter D.
Format: Article
Language:English
Subjects:
Diffusion-weighted imaging
Intracerebral hemorrhage
Perihemorrhagic edema
Perihemorrhagic ischemia
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cerebral ischemia has been proposed as a contributing mechanism to secondary neuronal injury after intracranial hemorrhage (ICH). The search for surrogate parameters that allow treatment stratification for spontaneous ICH continues. We aimed to examine perihemorrhagic ischemic changes with an animal experimental MRI study. A high field MRI compatible setup for male Wistar rats was established using a double injection model. ICH was stereotactically placed into the right basal ganglia of 29 Wistar rats. Coronal T2-WI, T2*-WI and DWI were generated with a 2.35 T animal MRI scanner 15 min, 60 min and 210 min after ICH. Clot signal characteristics, clot volumes and normalized ADC values were analyzed in four hematoma regions (core, periphery, outer rim, healthy ipsilateral tissue) in all sequences. T2*-WI and DWI reliably demonstrated ICH in 100% with only small deviation from the applied volume (−20% to +26%) whereas T2-WI failed to conspicuously show ICH. There were no perihemorrhagic ADC decreases consistent with ischemic cytotoxic edema but a mild vasogenic edema surrounding the ICH could be observed. T2*-WI and DWI are accurate for the diagnosis of hyperacute ICH. According to serial and crossectional ADC analysis, there is no hint towards the existence of a perihemorrhagic ischemic area that might be saved by early intervention. Future studies should focus on perfusion and metabolic/neurotoxic studies of this particular area and neurotoxic properties of the surrounding edema.
ISSN:0014-4886
1090-2430
DOI:10.1016/j.expneurol.2005.01.017