Preparation and characterisation of octenyl succinate starch as a delivery carrier for bioactive food components

• Published in: Food chemistry 2011-06, Vol.126 (3), p.1218-1225
• Main Authors: Wang, Xueyu, Li, Xiaoxi, Chen, Ling, Xie, Fengwei, Yu, Long, Li, Bing
• Format: Article
• Language: English
• Subjects: Bioactive food components; Biological and medical sciences; Delivery carrier; Esterification; Food industries; Fundamental and applied biological sciences. Psychology; Octenyl succinate starch; Starch and starchy product industries
• ISSN: 0308-8146; 1873-7072
• DOI: 10.1016/j.foodchem.2010.12.006

► Octenyl succinate starch with different higher DS is synthesised. ► Increased resistant starch content indicates better colon-targeting. ► Octenyl succinate starch can be a potential carrier for colon-targeted delivery. The octenyl succinic anhydride (OSA) modified corn starch (OSAS) was synthesised with different degrees of substitution (DS) and the influences of three factors namely OSA/starch ratio, reaction temperature, and reaction time on the DS of OSAS were studied by response surface methodology (RSM). As a delivery carrier material, the characteristics of OSAS were investigated. The resistant starch (RS) content of OSAS was increased with increasing DS, indicating the improvement of colon-targeting property. The swelling ratio (SR) of the OSAS in simulated gastrointestinal fluids was higher than that of native starch and its hydrophilicity was decreased with increasing DS. For in vitro release study, the percentage of released bioactive components was less than 7% within the first 8h and close to 100% over a period of 36h when the DS was 0.60. These results demonstrate that OSAS can be a potential carrier for colon-targeted delivery of bioactive food components.