Determination of element contents in herbal drugs: Chemometric approach

► This study is targeted to determine the element contents of 23 herbal drugs. ► Cd, Cr, Pb and Ni were lower than permissible limit as prescribed by WHO. ► Chemometric procedures appear useful tools for the classification of herbal drugs. ► Chemometrics can be used in quality control of drugs to en...

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Bibliographic Details
Published in:Food chemistry 2012-12, Vol.135 (4), p.2372-2377
Main Authors: Arumugam, Radjassegarin, Ragupathi Raja Kannan, Rengasamy, Jayalakshmi, Jayabalan, Manivannan, Karunamoorthy, Karthikai Devi, Gopalraj, Anantharaman, Perumal
Format: Article
Language:English
Subjects:
Biological and medical sciences
Elements
Food industries
Fundamental and applied biological sciences. Psychology
General aspects
Herbal drugs
Hygiene and safety
Multivariate Analysis
Permissible limits
Plants, Medicinal - chemistry
Principal Component Analysis
Safety
Trace Elements - analysis
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Summary:► This study is targeted to determine the element contents of 23 herbal drugs. ► Cd, Cr, Pb and Ni were lower than permissible limit as prescribed by WHO. ► Chemometric procedures appear useful tools for the classification of herbal drugs. ► Chemometrics can be used in quality control of drugs to ensure their safety. The elemental content of 23 commercial herbal drugs was evaluated and multivariate analysis such as principal component analysis (PCA) and hierarchical cluster analysis (HCA) were performed with aim to know the relationship among the elements in the herbal drugs. Among the 13 elements investigated K (8096.97), Na (581.53), Cu (2.06); Mg (678.4); Fe (476.93), Al (321.5), Co (0.22); Zn (4.46), Ni (0.56); Mn (25.77); Pb (13.33); and Cr (13.18)mg/kg dry weight, respectively, were found at high concentrations in Eclipta prostrata; Adhatoda vasica; Phyllanthus amarus; Hybanthus enneaspermus; Cardiospermum halicacabum; Acacia nilotica; and Denolix elata. Interestingly, the toxic element Cd was below detectable level in all the samples and Cr, Pb and Ni were lower than the permissible limit as prescribed by the World Health Organisation (WHO). This study clearly shows that PCA and HCA procedures appear useful tools for the differentiation and classification of herbal drugs using the profile of elements.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2012.07.040