OR51 Correlation of class II antibody development with acute cellular rejection and fibrosis in pediatric liver transplantation

• Published in: Human immunology 2017-09, Vol.78, p.47-47
• Main Authors: Bow, Laurine M., Ekong, Udeme, Morotti, Raffaella, Antala, Swati, Emre, Sukru
• Format: Article
• Language: English
• ISSN: 0198-8859; 1879-1166
• DOI: 10.1016/j.humimm.2017.06.057

The significance of HLA antibody in liver transplantation has been unclear, although recent studies have described an increase in the diagnosis of antibody mediated damage in this population. Our specific aim is to correlate the development of de novo HLA antibody including C1q testing, and AT1R antibody levels with graft dysfunction to determine if there is a significant association of these antibodies with graft function. 63 patients at our center from 7/31/1998 to 2/29/16 were included for analysis, of which 42 were screened for Anti-HLA DSA, C1q and AT1R. DSA >1000mfi was considered positive and patients were evaluated retrospectively for ACR. Specificity of antibody locus as well as alleles were analyzed and correlated with liver dysfunction. Available biopsies were evaluated for rejection grade, mean fibrosis score as well as portal, central, and sinusoidal fibrosis. Patient characteristics were summarized using mean, standard deviation, median and range for continuous variable, frequency and percentage for categorical variable. Wilcoxon Rank Sum or Kruskal Wallace test was conducted to check differences of continuous variables. Two sided p value less than 0.05 was considered as statistically significant. Portal fibrosis scores were significantly lower in patients without Class II DQ DSA post transplant (p