Peroxidase-like biomimetic epoxidation and subsequent alcoholysis of olefins by Fe(III)tetrakis(4-sulphonatophenyl) porphyrin (Fe4SP) encapsulated in the metal-organic framework HKUST-1

• Published in: Inorganica Chimica Acta 2023-07, Vol.552, p.121483, Article 121483
• Main Authors: Magnuson, Zachary L, Larsen, Randy W
• Format: Article
• Language: English
• Subjects: Biomimetic; Catalysis; Epoxidation; Heme; HKUST-1; Peroxidase
• ISSN: 0020-1693; 1873-3255
• DOI: 10.1016/j.ica.2023.121483

[Display omitted] •The Fe4SP@HKUST-1 heme coupled metal organic framework homogeneous catalyst displays tandem epoxidation-methanolysis with good stability and high turnover numbers.•The Fe4SP@HKUST-1 systems displays high selectivity in product yield.•Additional advantages to this catalyst include ease of synthesis, good recyclability and stability, and cost-effective starting materials.•The extraordinarily large library of existing MOFs and correspondingly large number of monooxygenase catalysts offer exceptional opportunities for future catalyst development. The efficiency and diverse functionality of biological catalysts has inspired the synthetic design of systems to mimic the stabilizing and catalytic properties of enzyme substrate binding protein pockets. One such system is the Fe4SP@HKUST-1 metal organic framework (MOF) system, also known as MOMzyme-1, in which Fe(III)tetrakis(4-sulphonatophenyl)porphyrin (Fe4SP) is encapsulated within the cuboctahedral cavities of the HKUST-1 MOF. Within this system the Fe4SP heme active site is encapsulated in a pseudo protein pocket within the MOF. Here, the ability of the Fe4SP@HKUST-1 to catalyze the tandem epoxidation of olefins followed by selective alcoholysis is examined. It is observed that encapsulation of Fe4SP within the MOF framework significantly enhances the turnover number (TON) of peroxide-driven epoxidation of styrene while greatly reducing metalloporphyrin degradation and maintaining stereoisomer selectivity. The Fe4SP@HKUST-1 catalyzes both the olefin epoxidation and the subsequent ring opening through the addition of CH3OH. The epoxidation of styrene occurs through the hydrogen peroxide generated high valent Fe(IV) = O of the encapsulated Fe4SP while the corresponding ring opening and methanolysis takes place at the Cu metallo building blocks of the HKUST-1 framework. These results provide a framework through which to develop a more extensive library of bio-inspired heme-based MOF catalysts.