Tuberculosis in assisted reproduction and infertility

The incidence of tuberculosis (TB) has declined in the developed countries; however, the disease continues to be an important cause of tubal factor infertility in the developing world. Tubal affliction is the rule, and fibrotic squeal of the infection result in tubal occlusion that is not amenable t...

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Bibliographic Details
Published in:International Congress series 2004-04, Vol.1266, p.287-294
Main Authors: Gurgan, Timur, Demirol, Aygül
Format: Article
Language:English
Subjects:
Infertility
Treatment
Tuberculosis
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Summary:The incidence of tuberculosis (TB) has declined in the developed countries; however, the disease continues to be an important cause of tubal factor infertility in the developing world. Tubal affliction is the rule, and fibrotic squeal of the infection result in tubal occlusion that is not amenable to reconstructive tubal surgery. Genital tuberculosis often exists without any symptoms or clinical signs. The most common initial symptom of genital tuberculosis is infertility; the other symptoms are lower abdominal and pelvic pain and menstrual abnormalities. Endometrial involvement is noted in 50% to 60% of subjects. In vitro fertilization (IVF) appears to be the only option for women suffering from infertility due to genital tuberculosis; however, endometrial involvement diminishes successful implantation. The success rates with IVF may be improved by adequate preoperative antituberculous chemotherapy and selection of patients without endometrial involvement, as shown by normal configuration of endometrial cavity at hysterosalpingography and a normal hysteroscopy. Patient selection for IVF should be performed carefully and the evaluation of each patient should be done fastidiously.
ISSN:0531-5131
1873-6157
DOI:10.1016/j.ics.2004.01.119