The safety and immunogenicity of influenza vaccine in children with asthma in Mexico

Summary Background The morbidity and mortality associated with influenza is substantial in children with asthma. There are no available data on the safety and immunogenicity of influenza vaccine in children with asthma in Latin America. Furthermore, it is unclear if influenza vaccination may cause a...

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Bibliographic Details
Published in:International journal of infectious diseases 2009-07, Vol.13 (4), p.469-475
Main Authors: Pedroza, Alvaro, Huerta, José G, de la Luz Garcia, Maria, Rojas, Arsheli, López-Martínez, Irma, Penagos, Martín, Franco-Paredes, Carlos, Deroche, Christele, Mascareñas, Cesar
Format: Article
Language:English
Subjects:
Asthma
Asthma - chemically induced
Asthma - immunology
Biological and medical sciences
Child
Child, Preschool
Chronic obstructive pulmonary disease, asthma
Double-Blind Method
Female
Forced expiratory volume (FEV)
Human viral diseases
Humans
Immunogenicity
Infectious Disease
Infectious diseases
Influenza
Influenza Vaccines - adverse effects
Influenza Vaccines - immunology
Influenza Vaccines - standards
Male
Medical sciences
Mexico
Placebos
Pneumology
Pulmonary/Respiratory
Respiratory Function Tests
Safety
Vaccine
Vaccines, Inactivated - adverse effects
Vaccines, Inactivated - immunology
Vaccines, Inactivated - standards
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
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Summary:Summary Background The morbidity and mortality associated with influenza is substantial in children with asthma. There are no available data on the safety and immunogenicity of influenza vaccine in children with asthma in Latin America. Furthermore, it is unclear if influenza vaccination may cause asthma exacerbations. Methods We conducted a placebo-controlled trial to investigate the safety and immunogenicity of an inactivated trivalent split virus influenza vaccine in children with asthma in Mexico. We also measured the impact of influenza vaccination on pulmonary function tests in this population. Results The inactivated influenza vaccine was immunogenic and safe in terms of local and systemic side effects compared to placebo. We observed no significant impact on pulmonary function tests among vaccine recipients. Conclusions Given the significant morbidity associated with influenza in children, strategies to promote increased influenza vaccination coverage in this high-risk group in Latin America and elsewhere are urgently needed.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2008.08.015