CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor

Improvements in tumor immunotherapies depend on better understanding of the anti-tumor T cell response. By studying human tumor-draining lymph nodes (TDLNs), we found that activated CD8+ T cells in TDLNs shared functional, transcriptional, and epigenetic traits with TCF1+ stem-like cells in the tumo...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2023-01, Vol.56 (1), p.107-124.e5
Main Authors: Prokhnevska, Nataliya, Cardenas, Maria A., Valanparambil, Rajesh M., Sobierajska, Ewelina, Barwick, Benjamin G., Jansen, Caroline, Reyes Moon, Adriana, Gregorova, Petra, delBalzo, Luke, Greenwald, Rachel, Bilen, Mehmet Asim, Alemozaffar, Mehrdad, Joshi, Shreyas, Cimmino, Cara, Larsen, Christian, Master, Viraj, Sanda, Martin, Kissick, Haydn
Format: Article
Language:English
Subjects:
Animals
antigen-presenting cells
cancer
CD8 T cells
CD8-Positive T-Lymphocytes
Cell Differentiation
co-stimulation
Humans
Lymph Nodes
Lymphocyte Activation
Mice
Neoplasms - pathology
T cell differentiation
T cell exhaustion
tumor-draining lymph nodes
tumor-infiltrating lymphocytes
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