CXCR3 expression in regulatory T cells drives interactions with type I dendritic cells in tumors to restrict CD8+ T cell antitumor immunity

Infiltration of regulatory T (Treg) cells, an immunosuppressive population of CD4+ T cells, into solid cancers represents a barrier to cancer immunotherapy. Chemokine receptors are critical for Treg cell recruitment and cell-cell interactions in inflamed tissues, including cancer, and thus are an id...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2023-07, Vol.56 (7), p.1613-1630.e5
Main Authors: Moreno Ayala, Mariela A., Campbell, Timothy F., Zhang, Chenyu, Dahan, Noa, Bockman, Alissa, Prakash, Varsha, Feng, Lawrence, Sher, Theo, DuPage, Michel
Format: Article
Language:English
Subjects:
cancer
CD8-Positive T-Lymphocytes
checkpoint blockade
cross presentation
CXCR3
dendritic cells
Dendritic Cells - metabolism
Humans
Immunotherapy
Neoplasms - metabolism
Receptors, CXCR3 - genetics
Receptors, CXCR3 - metabolism
regulatory T cells
T-Lymphocytes, Regulatory
Tregs
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