Synthesis of antioxidant and antibacterial active quinazolinones by carboxymethyl cellulose@MnFe2O4 biocatalyst

• Published in: Inorganic chemistry communications 2023-12, Vol.158, p.111556, Article 111556
• Main Authors: Rahimi, Saeed, Nezhad, Shefa Mirani, Zare, Ehsan Nazarzadeh, Pourmousavi, Seied Ali, Boroujerdian, Mohiedin, Hosseini, Samanesadat
• Format: Article
• Language: English
• Subjects: Biodegradable catalyst; Carboxymethyl cellulose; Nanocomposite; Quinazolinone derivatives
• ISSN: 1387-7003; 1879-0259
• DOI: 10.1016/j.inoche.2023.111556

[Display omitted] •A magnetic nanocomposite based on carboxymethyl cellulose@MnFe2O4 was prepared.•Magnetic nanocomposite used as a catalyst for synthesis of quinazoline derivatives.•Antioxidant and antibacterial activities of quinazoline derivatives was studied. Quinazolinones are a class of organic compounds that have attracted significant attention in medicinal chemistry and pharmacology due to their diverse biological activities and potential therapeutic applications. In the present study, a biocomposite, based on cross-linked ionic carboxymethyl cellulose and manganese ferrite (CCMC@MnFe2O4), was designed in three steps. The prepared biocomposite was comprehensively characterized using various analytical techniques, including EDX, FESEM, XRD, FTIR, VSM, and TGA instruments. The XRD and FESEM analyses of the CCMC@MnFe2O4 revealed a semicrystalline pattern and polyhedral morphology, respectively. The CCMC@MnFe2O4 biocomposite was employed as a catalyst for the preparation of quinazolinones. The results showed that quinazolinone derivatives were obtained in high yield (>85%) using 0.07 g of CCMC@MnFe2O4 with reaction times ranging from 30 to 60 min in ethanol solvent. CCMC@MnFe2O4 could be easily separated from the reaction using a magnet and reused over five consecutive cycles without a significant loss of efficiency. The prepared quinazolinones exhibited antioxidant activity (ranging from 65% to 92%) and demonstrated antimicrobial activity against both E. coli (with an inhibition zone of 7–10 mm) and S. aureus (with an inhibition zone of 8–12 mm). Some of the benefits of this study include a straightforward method, a short reaction duration, a considerable yield, and the ability to reuse and maintain the stability of the catalyst.