Poor Responsiveness to Clopidogrel: Drug-Specific or Class-Effect Mechanism?

Poor Responsiveness to Clopidogrel: Drug-Specific or Class-Effect Mechanism? Evidence From a Clopidogrel-to-Ticlopidine Crossover Study Gianluca Campo, Marco Valgimigli, Donato Gemmati, Gianfranco Percoco, Linda Catozzi, Alice Frangione, Federica Federici, Fabrizio Ferrari, Matteo Tebaldi, Serena Lu...

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Published in:Journal of the American College of Cardiology 2007-09, Vol.50 (12), p.1132-1137
Main Authors: Campo, Gianluca, MD, Valgimigli, Marco, MD, PhD, Gemmati, Donato, MS, Percoco, Gianfranco, MD, Catozzi, Linda, MS, Frangione, Alice, MD, Federici, Federica, MS, Ferrari, Fabrizio, MD, Tebaldi, Matteo, MD, Luccarelli, Serena, MD, Parrinello, Giovanni, PhD, Ferrari, Roberto, MD, PhD
Format: Article
Language:English
Subjects:
Cardiovascular
Internal Medicine
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Summary:Poor Responsiveness to Clopidogrel: Drug-Specific or Class-Effect Mechanism? Evidence From a Clopidogrel-to-Ticlopidine Crossover Study Gianluca Campo, Marco Valgimigli, Donato Gemmati, Gianfranco Percoco, Linda Catozzi, Alice Frangione, Federica Federici, Fabrizio Ferrari, Matteo Tebaldi, Serena Luccarelli, Giovanni Parrinello, Roberto Ferrari In 143 patients undergoing percutaneous coronary intervention, poor responsiveness to either clopidogrel or ticlopidine at steady state was common, whereas nonresponders to both drugs were relatively infrequent (3.5%, 95% confidence interval 1.5% to 7.9%), suggesting a drug-specific mechanism.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2007.04.092