Atypical antipsychotics related metabolic syndrome in bipolar patients

• Published in: Journal of affective disorders 2007-03, Vol.98 (3), p.247-252
• Main Authors: Yumru, Mehmet, Savas, Haluk A, Kurt, Erhan, Kaya, M. Cemal, Selek, Salih, Savas, Esen, Oral, E. Timucin, Atagun, Ilhan
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Adult and adolescent clinical studies; Antipsychotic Agents - adverse effects; Antipsychotic Agents - therapeutic use; Atypical antipsychotics; Benzodiazepines - therapeutic use; Biological and medical sciences; Bipolar disorder; Bipolar Disorder - diagnosis; Bipolar Disorder - drug therapy; Bipolar Disorder - epidemiology; Bipolar disorders; Body Mass Index; Carbamazepine - therapeutic use; Cross-Sectional Studies; Diagnostic and Statistical Manual of Mental Disorders; Dibenzothiazepines - therapeutic use; Female; Humans; Lithium Carbonate - therapeutic use; Male; Medical sciences; Metabolic diseases; Metabolic syndrome; Metabolic Syndrome - diagnosis; Metabolic Syndrome - epidemiology; Middle Aged; Miscellaneous; Mood disorders; Mood stabilizers; Neuropharmacology; Other metabolic disorders; Pharmacology. Drug treatments; Prevalence; Psychiatry; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Quetiapine Fumarate; Risperidone - therapeutic use; Severity of Illness Index; Triazines - therapeutic use; Valproic Acid - therapeutic use
• ISSN: 0165-0327; 1573-2517
• DOI: 10.1016/j.jad.2006.08.009

Abstract Background This is the first study in bipolar patients, aimed to evaluate possible roles of the drugs, [atypical antipsychotics (AA) and mood stabilizers (MS)], inducing metabolic syndrome (MetS). Methods 125 bipolar patients, diagnosed according to the DSM IV, were assessed cross-sectionally for MetS according to the National Cholesterol Educational Program criteria (NCEP ATP III). Patients included in the study were required to receive medications (AAs: quetiapine, risperidone and olanzapine, and MSs: Lithium, Sodium Valproate, Carbamazepine, Lamotrigine) for at least 3 months. Patients are divided into three groups as only AA users, AA + MS users and only MS users. Results Of the patients, 32% were MetS, a proportion higher than normal population and similar as previous studies in bipolar patients. AA taking patients had significantly higher MetS rates than the others ( χ2 = 10.47 df = 2 p = 0.005). Also, AA taking patients had significantly higher MetS rates than MS taking patients ( χ2 = 8.86 df = 1 p = 0.003). There was no significant difference among quetiapine, olanzapine, risperidone usage for MetS prevalences ( χ2 = 0.38 df = 2 p = 0.82). Conclusions AA taking bipolar patients had higher MetS rates. Despite already existing data on MetS and antipsychotics, this cross-sectional study is the first research, discusses AAs and MSs for inducing MetS in bipolar disorder. Prospectively designed researches should be conducted for further clarification of the role of these drugs in MetS.