Anti-diarrheal and spasmolytic activities and acute toxicity study of Soonkijangquebo, a herbal anti-diarrheal formula

The anti-diarrheal and spasmolytic activities of Soonkijangquebo™ (SKJQB), a Korean herbal anti-diarrheal formulation, were subjected to pharmacological evaluation. SKJQB, at a dose of 50–200 mg/kg, inhibited castor oil-induced diarrhea in mice. The median effective dose (ED 50) for the anti-diarrhe...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2004-03, Vol.91 (1), p.75-80
Main Authors: Ryu, Seung-Duk, Park, Chang-Shin, Baek, Hyun-Moon, Baek, Sun-Hye, Hwang, Sung-Yeoun, Chung, Woon-Gye
Format: Article
Language:English
Subjects:
Animals
Anti-diarrhea
antidiarrheal effect
Antidiarrheals - adverse effects
Antidiarrheals - therapeutic use
Biological and medical sciences
Calcium antagonist
Calcium Channel Blockers - adverse effects
Calcium Channel Blockers - therapeutic use
diarrhea
Female
General pharmacology
Guinea Pigs
herbal medicines
Korea
Male
Medical sciences
medicinal properties
Medicine, Traditional
Mice
Mice, Inbred ICR
Parasympatholytics - adverse effects
Parasympatholytics - therapeutic use
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Preparations - adverse effects
Plant Preparations - isolation & purification
Plant Preparations - therapeutic use
Rabbits
Rats
Rats, Sprague-Dawley
Soonkijangquebo
Spasmolytic
spasmolytic activity
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Summary:The anti-diarrheal and spasmolytic activities of Soonkijangquebo™ (SKJQB), a Korean herbal anti-diarrheal formulation, were subjected to pharmacological evaluation. SKJQB, at a dose of 50–200 mg/kg, inhibited castor oil-induced diarrhea in mice. The median effective dose (ED 50) for the anti-diarrheal effect was 93 mg/kg. In isolated rabbit jejunum preparations, SKJQB produced a spasmolytic effect by the relaxation of spontaneous contractions in a dose-dependent manner. The median effective concentration (EC 50) for the spasmolytic effect was 3.6 mg/ml. In isolated guinea pig ileum preparations, SKJQB also produced a spasmolytic effect by reduction of acetylcholine-induced contractions. When tested against calcium channel blockade in rabbit jejunum, SKJQB caused a dose-dependent rightward shift in the Ca 2+ dose–response curves, similar to that produced by verapamil, a well-known calcium antagonist. In an acute toxicity study in Sprague–Dawley rats, the median lethal dose (LD 50) of SKJQB was greater than 2000 mg/kg, and no pathological changes were noticed in macroscopic examination by necropsy of rats treated with SKJQB. Thus, SKJQB may be safely used as a spasmolytic as well as an anti-diarrheal agent.
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2003.11.019