Antinociceptive and anti-inflammatory activities of Philodendron bipinnatifidum Schott ex Endl (Araceae)

Popular medicine use stems of Philodendron bipinnatifidum (Araceae) in inflammation cases, such as in erysipelas, as well as orchitis and rheumatism treatment. The present study, conducted for the first time in literature, investigate the antinociceptive and anti-inflammatory activities of P. bipinn...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2019-05, Vol.236, p.21-30
Main Authors: Scapinello, Jaqueline, Müller, Liz Girardi, Schindler, Monica S.Z., Anzollin, Gabriela Sabrina, Siebel, Anna Maria, Boligon, Aline A., Niero, Rivaldo, Saraiva, Thalia E.S., Maus, Nathália Pulz, Betti, Andresa Heemann, Oliveira, J. Vladimir, Magro, Jacir Dal, de Oliveira, Débora
Format: Article
Language:English
Subjects:
Antinociception
Inflammatory pain
Medicinal plant
Philodendron bipinnatifidum
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Summary:Popular medicine use stems of Philodendron bipinnatifidum (Araceae) in inflammation cases, such as in erysipelas, as well as orchitis and rheumatism treatment. The present study, conducted for the first time in literature, investigate the antinociceptive and anti-inflammatory activities of P. bipinnatifidum stems ethyl acetate extract (EPB). GC/MS and HPLC analysis were performed for EPB extract. We used EPB at 250, 375 and 500 mg/kg (oral route, p.o.) in male Swiss mice. The antinociceptive activity of the plant extract assessed by acetic acid induced writhing and formalin tests. To investigate the possible participation of opioid system in EPB-mediated effects, we previously administered naloxone to the mice. Anti-inflammatory activity was evaluated using carrageenan-induced paw oedema. The open-field test aimed to investigate the possible EPB effects on the locomotor and exploratory activities. To assess the protective role of EPB on carrageenan-induced oxidative stress, the levels of NPSH, TBARS, as well as SOD and CAT activities were evaluated in blood and paw tissue. The acute toxicity of the EPB was investigated using OECD 423 guideline. The EPB chemical analysis by GC/MS and HPLC revealed the presence of flavonoids (luteolin and quercetin) and phytosterols (β-sitosterol and stigmasterol). The oral treatment with the EPB inhibited mice abdominal writhings (P 
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2019.02.037