Case report: Identification of recombinant HCV genotype 1b–2b by viral sequencing in two patients with treatment failure, who responded to re-treatment with sofosbuvir and daclatasvir

Hepatitis C virus (HCV) infection is a global health problem. HCV has been classified into seven genotypes and >67 subtypes. Genotyping is necessary to enable selection of appropriate treatments. The commercial molecular techniques currently used do not identify some HCV subtypes, mixed infection...

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Bibliographic Details
Published in:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2018-11, Vol.24 (11), p.928-931
Main Authors: Uribe-Noguez, Luis Antonio, Ocaña-Mondragón, Alicia, Mata-Marín, José Antonio, Cázares-Cortázar, Allison, Ribas-Aparicio, Rosa María, Gómez-Torres, María Elena, Gaytán-Martínez, Jesus, Martínez-Rodríguez, María de la Luz
Format: Article
Language:English
Subjects:
Adult
Antiviral Agents - therapeutic use
Drug Therapy, Combination - methods
Female
Genotype 1b-2b
Genotyping Techniques
Hepacivirus - genetics
Hepacivirus - isolation & purification
Hepatitis C - drug therapy
Hepatitis C - virology
Hepatitis C virus
Humans
Imidazoles - therapeutic use
Male
Middle Aged
Phylogenetic analysis
Recombination
Retreatment - methods
RNA, Viral - isolation & purification
Sequence Analysis, RNA
Sequencing
Sofosbuvir - therapeutic use
Sustained Virologic Response
Treatment Failure
Viral Nonstructural Proteins - genetics
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