High-energy breakfast based on whey protein reduces body weight, postprandial glycemia and HbA 1C in Type 2 diabetes

• Published in: The Journal of nutritional biochemistry 2017-11, Vol.49, p.1-7
• Main Authors: Jakubowicz, Daniela, Wainstein, Julio, Landau, Zohar, Ahren, Bo, Barnea, Maayan, Bar-Dayan, Yosefa, Froy, Oren
• Format: Article
• Language: English
• Subjects: Blood Glucose - analysis; Body Mass Index; Breakfast; Combined Modality Therapy; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diet therapy; Diabetes Mellitus, Type 2 - drug therapy; Diet, Diabetic; Diet, Reducing; Energy Intake; Female; Glycated Hemoglobin A - analysis; Humans; Hyperglycemia - prevention & control; Hypoglycemic Agents - therapeutic use; Male; Metformin - therapeutic use; Middle Aged; Obesity - complications; Obesity - diet therapy; Satiety Response; Weight Loss; Whey Proteins - therapeutic use
• ISSN: 0955-2863; 1873-4847
• DOI: 10.1016/j.jnutbio.2017.07.005

Acute studies show that addition of whey protein at breakfast has a glucose-lowering effect through increased incretin and insulin secretion. However, whether this is a long-term effect in Type 2 diabetes is unknown. Fifty-six Type 2 diabetes participants aged 58.9±4.5 years, BMI 32.1±0.9 kg/m and HbA 7.8±0.1% (61.6±0.79 mmol/mol) were randomized to one of 3 isocaloric diets with similar lunch and dinner, but different breakfast: 1) 42 g total protein, 28 g whey (WBdiet, n=19); 2) 42 g various protein sources (PBdiet, n=19); or 3) high-carbohydrate breakfast, 17 g protein from various sources (CBdiet, n=18). Body weight and HbA were examined after 12 weeks. All participants underwent three all-day meal challenges for postprandial glycemia, insulin, C-peptide, intact glucagon-like peptide 1 (iGLP-1), ghrelin and hunger and satiety scores. Overall postprandial AUC was reduced by 12% in PBdiet and by 19% in WBdiet, compared with CBdiet (P