Evaluation of S201086/GLPG1972, an ADAMTS-5 inhibitor, for the treatment of knee osteoarthritis in ROCCELLA: a phase 2 randomized clinical trial

To evaluate the efficacy and safety of the anti-catabolic ADAMTS-5 inhibitor S201086/GLPG1972 for the treatment of symptomatic knee osteoarthritis. ROCCELLA (NCT03595618) was a randomized, double-blind, placebo-controlled, dose-ranging, phase 2 trial in adults (aged 40–75 years) with knee osteoarthr...

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Bibliographic Details

Published in:	Osteoarthritis and cartilage 2023-07, Vol.31 (7), p.985-994
Main Authors:	Schnitzer, T., Pueyo, M., Deckx, H., van der Aar, E., Bernard, K., Hatch, S., van der Stoep, M., Grankov, S., Phung, D., Imbert, O., Chimits, D., Muller, K., Hochberg, M.C., Bliddal, H., Wirth, W., Eckstein, F., Conaghan, P.G.
Format:	Article
Language:	English
Subjects:	Adult Double-Blind Method Humans Knee Knee Joint - diagnostic imaging Knee Joint - pathology Magnetic resonance imaging Osteoarthritis Osteoarthritis, Knee - diagnostic imaging Osteoarthritis, Knee - drug therapy Pain - pathology Rheumatology Therapeutics Treatment Outcome
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